JoJo, while traveling in England, wakes up in 19th-century Britain. Seeing an opportunity to become a renowned scientist in this less technologically advanced era, he sets out to make a name for himself. However, his plans are interrupted when he encounters DIO, a blond man who seems to know more than he lets on. JoJo soon realizes this isn't the world he knows and becomes a vampire. His journey takes him through various worlds inspired by JoJo's Bizarre Adventure, Demon Slayer, and Inuyasha, leading him on a bizarre and perilous adventure.